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Asthma MOD CRS with Nasal Polyposis MOD Atopic Dermatitis MOD Dr Blaiss: Critical Roles for Type 2 Cytokines in the Pathobiology for Asthma Dr Busse: Connecting Type 2 Inflammation to Asthma Exacerbations Dr Panettieri: Airway Remodeling in Asthma Dr Beck: Nonlesional Skin Is Not Normal Dr Boguniewicz:
IL-4 and IL-13 in Atopic Dermatitis Epithelial Barrier Dysfunction Type 2 Cytokines Exacerbations and Lung Function

Different Manifestations Across Patients
Type 2 Inflammation May Be A Clear Connection

Type 2 inflammation, which can be both systemic and local, contributes to immune dysregulation and epithelial barrier dysfunction^1,5

CRS, chronic rhinosinusitis.

References: 1. Gandhi NA, Bennett BL, Graham NMH, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016;15(1):35-50. 2. Kocatürk E, Maurer M, Metz M, Grattan C. Looking forward to new targeted
treatments for chronic spontaneous urticaria. Clin Transl Allergy. 2017;7:1. Published correction appears in: Clin Transl Allergy. 2017;7:11. 3. Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev. 2018;282(1):121-150.
4. Weigelt N, Metze D, Ständer S. Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients. J Cutan Pathol. 2010;37(5):578-586. 5. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2021. Accessed October 28, 2021.
https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V2-WMS.pdf

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CRS, chronic rhinosinusitis.

References: 1. Gandhi NA, Bennett BL, Graham NMH, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016;15(1):35-50. 2. Kocatürk E, Maurer M, Metz M, Grattan C. Looking forward to new targeted
treatments for chronic spontaneous urticaria. Clin Transl Allergy. 2017;7:1. Published correction appears in: Clin Transl Allergy. 2017;7:11. 3. Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev. 2018;282(1):121-150.
4. Weigelt N, Metze D, Ständer S. Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients. J Cutan Pathol. 2010;37(5):578-586. 5. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2021. Accessed October 28, 2021.
https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V2-WMS.pdf