Printed From:

IL-4, IL-13, AND IL-5 ARE KEY DRIVERS
OF TYPE 2 INFLAMMATION IN CRSwNP1

IL-4 and IL-13 are central Type 2 cytokines with distinct and overlapping roles in
chronic rhinosinusitis with nasal polyposis (CRSwNP) pathophysiology1,2

CRSwNP involves a distinct Type 2 profile, including1,3,4:

A lack of regulatory T cell (Treg) function

Local IgE production induced by IL-4 and IL-13

Eosinophilic
inflammation induced
by IL-4, IL-13, and IL-5

Olfactory dysfunction results in varying levels of loss of smell
ranging from decreased sense of smell to anosmia1

ILC2, type 2 innate lymphoid cells; TSLP, thymic stromal lymphopoietin.

References: 1. Akdis CA, Bachert C, Cingi C, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin lmmunol. 2013;131(6):1479-1490. 2. Gandhi NA, Bennett BL, Graham NMH, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016;15(1):35-50. 3. Stevens WW, Schleimer RP, Kern RC. Chronic rhinosinusitis with nasal polyps. J Allergy Clin lmmunol Pract. 2016;4(4):565-572. 4. Kato A. lmmunopathology of chronic rhinosinusitis. Allergol Int. 2015;64(2):121-130.