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TYPE 2 INFLAMMATION IS THE
UNDERLYING CAUSE OF CRSwNP
IN 80% OF PATIENTS1,a

CRSwNP is a clinical syndrome characterized by inflammation of the nose and paranasal sinuses1

Type 2 comorbidities are common, and often exacerbated, in patients with
chronic rhinosinusitis with nasal polyposis (CRSwNP)1-3

Click on the airways to reveal more Type 2 inflammation comorbidities

Comorbidities associated with CRSwNP3-5

Patients with severe asthma and CRSwNP have higher asthma symptom
scores, elevated exacerbation rates, and increased loss of smell
compared with asthma patients who have CRS without nasal polyposis3

Without treatment, CRSwNP can lead to6-8:

  • Loss of smell
  • Nasal obstruction/congestion that may cause difficulty with nasal breathing
  • Anterior/posterior rhinorrhea
  • Pain/pressure
  • Sleep disturbance
  • Chronic fatigue
  • Work absenteeism and reduced productivity

a In Western Countries.

AERD, aspirin-exacerbated respiratory disease; CRS, chronic rhinosinusitis; NSAID-ERD, nonsteroidal anti-inflammatory drug‒exacerbated respiratory disease; QoL, quality of life.

References: 1. Chaaban MR, Walsh EM, Woodworth BA. Epidemiology and differential diagnosis of nasal polyps. Am J Rhinol Allergy. 2013;27(6):473-478. 2. Bachert C, Gevaert E. Advances in rhinitis and rhinosinusitis in 2015. J Allergy Clin Immunol. 2016;138(5):1277-1283. 3. Langdon C, Mullol J. Nasal polyps in patients with asthma: prevalence, impact, and management challenges. J Asthma Allergy. 2016;9:45-53. 4. Gelardi M, Iannuzzi L, Tafuri S, Passalacqua G, Quaranta N. Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history. Acta Otorhinolaryngol Ital. 2014;34(1):36-41. 5. Stevens WW, Peters AT, Hirsch AG, et al. Clinical characteristics of patients with chronic rhinosinusitis with nasal polyps, asthma, and aspirin-exacerbated respiratory disease. J Allergy Clin lmmunol Pract. 2017;5(4):1061-1070.e3. 6. Bachert C, Pawankar R, Zhang L, et al. ICON: chronic rhinosinusitis. World Allergy Organ J. 2014;7(1):25. doi:10.1186/1939-4551-7-25 7. Palmer J, Messina J, Biletch R, Grosel K, Mahmoud R. Health care for chronic rhinosinusitis (CRS) symptoms—a cross-sectional, population-based survey of US adults meeting symptom criteria for CRS. Poster presented at: American Academy of Allergy, Asthma & Immunology Annual Meeting; March 3-6, 2017; Atlanta, GA. 8. Liu T, Cooper T, Earnshaw J, Cervin A. Disease burden and productivity cost of chronic rhinosinusitis patients referred to a tertiary centre in Australia. Aust J Otolaryngol. 2018;1:5. doi:10.21037/ajo.2018.01.03