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EoE IS A CHRONIC TYPE 2
INFLAMMATORY DISEASE1

Eosinophilic esophagitis (EoE) is characterized by difficulty swallowing due to inflammation in the esophagus.1,2 Patients may experience the following signs and symptoms:

Fibrosis of the esophagus
(narrowing and scarring)3

Present in 89% of patients with EoE with features including uniformity and hyalinization

Esophageal dysfunction,
particularly dysphagia3

A primary symptom directly associated with a diagnosis of EoE, characterized by difficulty swallowing

Food impaction2

One of the main symptoms of EoE, food impaction is a direct consequence of the esophageal fibrosis and mucosa remodeling

Chest pain3

Present in many patients with EoE

EoE is a progressive disease with long-term challenges that impact patients’ health-related quality of life, including4-7:

Adherence to strict diets Use of rescue drug therapy Esophageal dilation
EoE impacts health-related quality of life across multiple parameters,
leaving an unmet medical need for many patients7-9

Patients with EoE often have multiple Type 2 inflammatory diseases10

~75% of patients with EoE

have at least one comorbid Type 2 inflammatory disease10-12

Allergic rhinitis
Asthma
Atopic dermatitis
CRSwNP
Food allergies
References: 1. O’Shea KM, Aceves SS, Dellon ES, et al. Pathophysiology of eosinophilic esophagitis. Gastroenterology. 2018;154(2):333-345. 2. D’Alessandro A, Esposito D, Pesce M, Cuomo R, De Palma GD, Sarnelli G. Eosinophilic esophagitis: from pathophysiology to treatment. World J Gastrointest Pathophysiol. 2015;6(4):150-158. 3. Li-Kim-Moy JP, Tobias V, Day AS, Leach S, Lemberg DA. Esophageal subepithelial fibrosis and hyalinization are features of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011:52(2):147-153. 4. Mukkada V, Falk GW, Eichinger CS, King D, Todorova L, Shaheen NJ. Health-related quality of life and costs associated with eosinophilic esophagitis: a systematic review. Clin Gastroenterol Hepatol. 2018;16(4):495-503.e8. 5. Franciosi JP, Hommel KA, DeBrosse CW, et al. Quality of life in pediatric eosinophilic esophagitis: what is important to patients? Child Care Health Dev. 2012;38(4):477-483. 6. Lucendo AJ, Arias-González L, Molina-Infante J, Arias Á. Determinant factors of quality of life in adult patients with eosinophilic esophagitis. United European Gastroenterol J. 2018;6(1):38-45. 7. Furuta GT, Katzka DA. Eosinophilic esophagitis. N Engl J Med. 2015;373(17):1640-1648. 8. Lucendo AJ, Molina-Infante J, Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3):335-358. 9. Hirano I, Chan ES, Rank MA, et al. AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2020;124(5):416-423. 10. van Rhijn BD, Bredenoord AJ. Management of eosinophilic esophagitis based on pathophysiological evidence. J Clin Gastroenterol. 2017;51(8):659-668. 11. Jyonouchi S, Brown-Whitehorn TA, Spergel JM. Association of eosinophilic gastrointestinal disorders with other atopic disorders. Immunol Allergy Clin North Am. 2009;29(1):85-97. 12. Padia R, Curtin K, Peterson K, Orlandi RR, Alt J. Eosinophilic esophagitis strongly linked to chronic rhinosinusitis. Laryngoscope. 2016;126(6):1279-1283.