Eosinophil trafficking
Epithelial barrier dysfunction
Remodeling and fibrosis,
leading to strictures, rings, furrows, edema, exudates, and smooth muscle contraction
Fibrosis of the esophagus
Fibrosis gradually leads to stenosis (narrowing) in many patients with eosinophilic esophagitis
Dysphagia
Characterized by discomfort during meals due to difficulty swallowing
Food impaction and bolus removal
Food impaction is a direct consequence of esophageal fibrosis and tissue remodeling. Removal of food bolus impaction can involve an urgent endoscopic intervention
Chest pain (noncardiac)
Present in ~50% of patients with eosinophilic esophagitis
CRSwNP, chronic rhinosinusitis with nasal polyposis.
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