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EoE IS A CHRONIC TYPE 2
INFLAMMATORY DISEASE1

Understand the impact of Type 2 inflammation on symptoms of
eosinophilic esophagitis (EoE)2,3

Eosinophil trafficking

Epithelial barrier dysfunction

Remodeling and fibrosis, leading to strictures, rings, furrows, edema, exudates, and smooth muscle contraction

Eosinophilic esophagitis is characterized by difficulty swallowing due to inflammation in the esophagus. Patients may experience the following signs and symptoms1,4-7:

Fibrosis of the esophagus

Fibrosis gradually leads to stenosis (narrowing) in many patients with eosinophilic esophagitis

Dysphagia

Characterized by discomfort during meals due to difficulty swallowing

Food impaction and bolus removal

Food impaction is a direct consequence of esophageal fibrosis and tissue remodeling. Removal of food bolus impaction can involve an urgent endoscopic intervention

Chest pain (noncardiac)

Present in ~50% of patients with eosinophilic esophagitis

Eosinophilic esophagitis is a chronic, progressive inflammatory disease, characterized by histologic and endoscopic changes to the esophagus3,8,9:

Progressive remodeling and fibrosis may lead to esophageal strictures, which worsen dysphagia and may result in food impaction and require dilation8

Patients with EoE often have multiple Type 2 inflammatory diseases10-13

~75% of patients with EoE

have at least one comorbid Type 2 inflammatory disease

Allergic rhinitis
Asthma
Atopic dermatitis
CRSwNP
Food allergies

CRSwNP, chronic rhinosinusitis with nasal polyposis.

References: 1. O’Shea KM, Aceves SS, Dellon ES, et al. Pathophysiology of eosinophilic esophagitis. Gastroenterology. 2018;154(2):333-345. 2. Hill DA, Spergel JM. The immunologic mechanisms of eosinophilic esophagitis. Curr Allergy Asthma Rep. 2016;16(2):9. doi:10.1007/s11882-015-0592-3 3. Gomez Torrijos E, Gonzalez-Mendiola R, Alvarado M, et al. Eosinophilic esophagitis: review and update. Front Med (Lausanne). 2018;5:247. doi:10.3389/fmed.2018.00247 4. D’Alessandro A, Esposito D, Pesce M, Cuomo R, De Palma GD, Sarnelli G. Eosinophilic esophagitis: from pathophysiology to treatment. World J Gastrointest Pathophysiol. 2015;6(4):150-158. 5. Li-Kim-Moy JP, Tobias V, Day AS, Leach S, Lemberg DA. Esophageal subepithelial fibrosis and hyalinization are features of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011;52(2):147-153. 6. Mukkada V, Falk GW, Eichinger CS, King D, Todorova L, Shaheen NJ. Health-related quality of life and costs associated with eosinophilic esophagitis: a systematic review. Clin Gastroenterol Hepatol. 2018;16(4):495-503.e8. 7. Straumann A, Bussmann C, Zuber M, Vannini S, Simon H-U, Schoepfer A. Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients. Clin Gastroenterol Hepatol. 2008;6(5):598-600. 8. Dellon ES, Hirano I. Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology. 2018;154(2):319-332.e3. 9. Bolton SM, Kagalwalla AF, Wechsler JB. Eosinophilic esophagitis in children: endoscopic findings at diagnosis and post-intervention. Curr Gastroenterol Rep. 2018;20(1):4. doi:10.1007/s11894-018-0607-z 10. van Rhijn BD, Bredenoord AJ. Management of eosinophilic esophagitis based on pathophysiological evidence. J Clin Gastroenterol. 2017;51(8):659-668. 11. Jyonouchi S, Brown-Whitehorn TA, Spergel JM. Association of eosinophilic gastrointestinal disorders with other atopic disorders. Immunol Allergy Clin North Am. 2009;29(1):85-97. 12. Padia R, Curtin K, Peterson K, Orlandi RR, Alt J. Eosinophilic esophagitis strongly linked to chronic rhinosinusitis. Laryngoscope. 2016;126(6):1279-1283. 13. Chehade M, Jones SM, Pesek RD, et al. Phenotypic characterization of eosinophilic esophagitis in a large multi-center patient population from the consortium for food allergy research. J Allergy Clin Immunol Pract. 2018;6(5):1534-1544.e5.