CSU is a chronic
inflammatory skin
disease that may BE
A significant
burden and result
in a reduced
quality of life1

CSU is characterized by:


Presence of wheals and/or
angioedema for at least
6 weeks1


Intense itch, pain,
and burning2

Quality of life

Lowered quality of life3

Presence of wheals and/or angioedema for at least 6 weeks1,2

Wheals are central swellings
by reflex erythema. They
are accompanied by itching or a
burning sensation2

Angioedema is a sudden, pronounced
erythematous or skin-colored swelling
of the lower dermis and subcutis or
submucosa. It is sometimes
by pain rather than itch2

Intense itch1,2,4

Patients rate itch as the most
bothersome symptom of CSU2


Itch is worst during the evening/night,
when it can prevent patients from
asleep and/or can cause

Reduced quality of life3,5

Sleep disturbance

The majority of patients with CSU suffer from sleep deprivation and a consequential reduction in QoL5


Visible lesions can lead to emotional upset and withdrawal from social activities5

Mental health

The most common mental health disorders among patients with CSU are3,6:

  • Anxiety disorders (31%)
  • Mood disorders (29%)
  • Traumatic and stressor-related
    disorders (17%)

Work productivity

People with CSU also report their
disease leading to5:

  • Impairment at work (40%)
  • Staying away from work (13%)
  • Decrease in work productivity (33%)

CSU, chronic spontaneous urticaria.

References: 1. Maurer M, Weller K, Bindslev-Jensen C, et al. Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report. Allergy. 2011;66(3):317-330. 2. Saini SS. Chronic spontaneous urticaria: etiology and pathogenesis. Immunol Allergy Clin North Am. 2014;34(1):33-52. 3. Staubach P, Dechene M, Metz M, et al. High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria. Acta Derm Venereol. 2011;91(5):557-561. 4. Maurer M, Abuzakouk M, Bérard F, et al. The burden of chronic spontaneous urticaria is substantial: real-world evidence from ASSURE-CSU. Allergy. 2017;72(12):2005-2016. 5. Balp MM, Vietri J, Tian H, et al. The impact of chronic urticaria from the patient’s perspective: a survey in five European countries. Patient. 2015;8(6):551-558. 6. Konstantinou GN, Konstantinou GN. Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis. Clin Transl Allergy. 2019;9:42.