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A SIGNIFICANT UNMET MEDICAL
NEED REMAINS FOR MANY
PATIENTS WITH EoE1

Current standard-of-care therapies for
eosinophilic esophagitis (EoE) do not fully address Type 2 inflammation1-4

There remains an unmet need to reduce esophageal dysfunction and eosinophil-predominant inflammation in order to improve endoscopic signs, clinical symptoms, and quality of life in
patients with EoE.

Eosinophilic esophagitis management approaches include1,3-7:

  • Food elimination diets
  • Swallowed topical corticosteroids
  • Proton pump inhibitors (PPIs)
  • Esophageal dilation
  • Upper endoscopy for the management of esophageal food impaction
References: 1. Lucendo AJ, Molina-Infante J, Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3):335-358. 2. O’Shea KM, Aceves SS, Dellon ES, et al. Pathophysiology of eosinophilic esophagitis. Gastroenterology. 2018;154(2):333-345. 3. Wolf WA, Dellon ES. Eosinophilic esophagitis and proton pump inhibitors: controversies and implications for clinical practice. Gastroenterol Hepatol (N Y). 2014;10(7):427-432. 4. D’Alessandro A, Esposito D, Pesce M, Cuomo R, De Palma GD, Sarnelli G. Eosinophilic esophagitis: from pathophysiology to treatment. World J Gastrointest Pathophysiol. 2015;6(4):150-158. 5.Gomez Torrijos E, Gonzalez-Mendiola R, Alvarado M, et al. Eosinophilic esophagitis: review and update. Front Med (Lausanne). 2018;5:247. doi:10.3389/fmed.2018.00247 6. Bolton SM, Kagalwalla AF, Wechsler JB. Eosinophilic esophagitis in children: endoscopic findings at diagnosis and post-intervention. Curr Gastroenterol Rep. 2018;20(1):4. doi:10.1007/s11894-018-0607-z 7. Straumann A, Bussmann C, Zuber M, Vannini S, Simon H-U, Schoepfer A. Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients. Clin Gastroenterol Hepatol. 2008;6(5):598-600.